Long-Term Neuropathological Changes Associated with Cerebral Palsy in a Nonhuman Primate Model of Hypoxic-Ischemic Encephalopathy
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چکیده
منابع مشابه
Serial plasma metabolites following hypoxic-ischemic encephalopathy in a nonhuman primate model.
Biomarkers that indicate the severity of hypoxic-ischemic brain injury and response to treatment and that predict neurodevelopmental outcomes are urgently needed to improve the care of affected neonates. We hypothesize that sequentially obtained plasma metabolomes will provide indicators of brain injury and repair, allowing for the prediction of neurodevelopmental outcomes. A total of 33 Macaca...
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Introduction there are one million deaths from asphyxia in newborn annually. Management of this newborn is only supportive. Autologuse stem cell therapy may reduce mortality and long term morbidity. Outcome of asphyxiated newborn is related to damage CNS cells. Stem cells prevent Apoptosis and induce repairmen of injured neurons. Methods in a review study all article related to three keyword...
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OBJECTIVES To determine the long-term neurodevelopmental outcome for children after hypoxic-ischemic encephalopathy (HIE) without major disability, and to examine neonatal injury patterns detected on cerebral magnetic resonance imaging (MRI) in relation to later deficits. STUDY DESIGN Prospectively enrolled children with HIE and neonatal cerebral MRI data (n = 68) were examined at a mean age ...
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This study aimed to investigate changes of characteristics of neural stem cells (NSCs) in a neonatal rat with hypoxic-ischemic brain damage (HIBD) and provide effective method and time window for the treatment of hypoxic-ischemic encephalopathy (HIE). A total of 231 7-day-old neonatal SD rats were randomly divided into control, hypoxic and HIBD groups (n=77 per group). Each group was randomly d...
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This study investigated the effect of myocardial dysfunction on the cerebral hemodynamics in term infants with hypoxic-ischemic encephalopathy (HIE). We evaluated myocardial systolic and diastolic functional parameters and cerebral hemodynamic parameters in 40 term newborn infants with HIE and 30 healthy controls during the first 14 days of life using two-dimensional/pulsed Doppler ultrasound. ...
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ژورنال
عنوان ژورنال: Developmental Neuroscience
سال: 2017
ISSN: 0378-5866,1421-9859
DOI: 10.1159/000470903